If A is the brother of B; B is the sister of C; and C is the father of D, how D is related to A?
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If D is Male, the answer is Nephew.
If D is Female, the answer is Niece.
As the sex of D is not known, hence, the relation between D and A cannot be determined.
Note: Niece - A daughter of one's brother or sister, or of one's brother-in-law or sister-in-law. Nephew - A son of one's brother or sister, or of one's brother-in-law or sister-in-law.