In how many ways can the letters of the word COMBINATORICS be arranged so that no 2 vowels are together?
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There are 8 consanants, in which there is one repeat (C). Therefore, there are 2 8 ! ways to arrange just the consanants.
There are 9 spaces between the consanants. We must choose 2 places for the O's, 2 more for the I's, and one more for the A.
Therefore, the answer is 2 8 ! ( 2 9 ) ( 2 7 ) ⋅ 5 = 7 6 2 0 4 8 0 0 .