Sooooooo many ways!!!

By Principle of Inclusion and Exclusion (PIE) $\\$ $.\\$ We first calculate all the possible outcome when the restriction is not considered: $\\$ $9P5 \cdot 9P7 = 2743372800$ $\\$ Pick from 9 male students for 5 distinct role and pick from 9 female students for 7 distinct role $\\$ $.\\$ The we calculate the outcome in which Jovane is not male lead but Jean plays the young female $\\$ $(4\cdot8Pa+8P5)\cdot 8P6 = 270950400$ $\\$ [(All cases, when Jovane is playing but not male lead) + (All cases, when Jovane is not playing)] $\times$ (Jean is young female, then pick from 8 females for 6 role) $\\$ $.\\$ $2743372800 - 270950400 = 2472422400$