This is a calcdoku puzzle where each coloured box is a section.
If there is a solution what is the 4 numbers (left to right) from the top row.
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Starting with the green box: The only three numbers that work are 1+1+3, (EDIT: due to the restriction from the brown box, which must be 2 and 4 in some order), and since you cant have two 1's in the same row the you have 1 and 3 in the top row and 1 in the last empty space for the green box.
Then the first column is down to having 2, 3, and 4, which multiply to 24, so the last space in yellow box must be a 2.
Then column 2 will have a 1, 2, and 3 so the empty box in column two (column 2 row 3, grey box) will be a 4. So the rest of grey box multiplies to 6, which is 1x2x3.
Since the 1 in row 2 column 2 cancels out the top two grey boxes and you know that row 3 column 3 is the 1.
The 3 1's down the diagonal only leave row 4 column 4 open for the last 1. So the two empty spots in blue must be 3+4 to get the total up to 8.
The 4 in row 3 column 2 means the blue box 4 must go in row 4 column 3. This forces the 4 in row 1 to go in column 4 and the 2 in row 1 to go in column 3.
That fills the top row with 1324.
You can complete the puzzle easily from here but it is not necessary to get the correct solution.