What is the fewest number of derivatives one needs to compute so that becomes zero?
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With every derivative, the power on x n goes down by 1. That means it will require 499 derivatives in order for 5 6 8 x 4 9 9 to have an x 0 term, that is to become a constant. Because the derivative of a constant is zero, the desired result will be achieved after one more derivative bringing the total to 500 derivatives.